Functionally selective muscarinic M1
receptor agonist (EC50
values are 0.3, 5, 42, 52 and 92.5 nM at M1
receptors respectively). Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1
; delayed wash-resistant partial agonist activity at M2
; and delayed wash-resistant full agonist activity at M4
. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Importance and prospects for design of selective muscarinic agonists.
Jakubik et al.
Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists.
Heinrich et al.
The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat.
Stanhope et al.