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Xanomeline oxalate

Catalog #: 3569
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Xanomeline oxalate | CAS No. 141064-23-5 | mAChR M1 Agonists
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Description: Functionally selective M1 agonist

Chemical Name: 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate

Purity: ≥98%

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Citations (1)
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Biological Activity

Xanomeline oxalate is a functionally selective muscarinic M1 receptor agonist (EC50 values are 0.3, 5, 42, 52 and 92.5 nM at M1, M3, M5, M4 and M2 receptors respectively). Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.

Technical Data

M.Wt:
371.46
Formula:
C14H23N3OS.C2H2O4
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
141064-23-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Xanomeline oxalate

The citations listed below are publications that use Tocris products. Selected citations for Xanomeline oxalate include:

1 Citation: Showing 1 - 1

  1. STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
    Authors: Tian Et al.
    Scientific Reports  2016;6:36684

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