Chemical Name: 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate
Biological ActivityXanomeline oxalate is a functionally selective muscarinic M1 receptor agonist (EC50 values are 0.3, 5, 42, 52 and 92.5 nM at M1, M3, M5, M4 and M2 receptors respectively). Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Importance and prospects for design of selective muscarinic agonists.
Jakubik et al.
Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists.
Heinrich et al.
Citation for Xanomeline oxalate
The citations listed below are publications that use Tocris products. Selected citations for Xanomeline oxalate include:
1 Citation: Showing 1 - 1
STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
Authors: Tian Et al.
Scientific Reports 2016;6:36684
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