Catalog Number: 3569
Chemical Name: 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate
Biological Activity
Functionally selective muscarinic M1 receptor agonist (EC50 values are 0.3, 5, 42, 52 and 92.5 nM at M1, M3, M5, M4 and M2 receptors respectively). Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.
Technical Data
  • M.Wt:
    371.46
  • Formula:
    C14H23N3OS.C2H2O4
  • Solubility:
    Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    141064-23-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Importance and prospects for design of selective muscarinic agonists.
    Jakubik et al.
    Physiol.Res., 2008;57:S39
  2. Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists.
    Heinrich et al.
    Eur.J.Pharmacol., 2009;605:53
  3. The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat.
    Stanhope et al.
    J.Pharmacol.Exp.Ther., 2001;299:782
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Xanomeline oxalate include:

1 Citations: Showing 1 - 1

  1. STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
    Authors: Tian Et al.
    Scientific Reports 2016;6:36684?

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