Chemical Name: (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Biological ActivityXanthohumol is a p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50 = 50.3 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein.
Sasazawa et al.
ACS Chem.Biol., 2012;7:892
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.
Tabata et al.
Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes.
Inokoshi et al.
Citation for Xanthohumol
The citations listed below are publications that use Tocris products. Selected citations for Xanthohumol include:
1 Citation: Showing 1 - 1
Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
Authors: den Brok Et al.
Nature Communications 2016;7:13324
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