Catalog Number: 4686
Chemical Name: (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Biological Activity
p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50 = 50.3 μM).
Technical Data
  • M.Wt:
    354.4
  • Formula:
    C21H22O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    6754-58-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein.
    Sasazawa et al.
    ACS Chem.Biol., 2012;7:892
  2. Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.
    Tabata et al.
    Phytochemistry, 1997;46:683
  3. Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes.
    Inokoshi et al.
    J.Antibiot.(Tokyo), 2009;62:51
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Xanthohumol include:

1 Citations: Showing 1 - 1

  1. Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
    Authors: den Brok Et al.
    Nature Communications 2016;7:13324

Have you used Xanthohumol?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information