Valosin-containing protein (VCP) inhibitor. Binds to the N domain of VCP, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50
= 50.3 μ
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Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein.
Sasazawa et al.
ACS Chem.Biol., 2012;7:892
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.
Tabata et al.
Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes.
Inokoshi et al.