Catalog Number: 6061
Chemical Name: 5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Biological Activity
Potent Ack1/TNK2 inhibitor (IC50 = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations respectively). Blocks phosphorylation of TNK2 receptors containing solid-tumor type truncation mutations.
Technical Data
  • M.Wt:
    445.52
  • Formula:
    C24H27N7O2
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    1234480-46-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.
Background References
  1. Development and repurposing of small-molecule kinase inhibitors to target novel leukemogenic TNK2 mutations
    Maxson et al.
    Blood, 2014;124:435
  2. Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis.
    Maxson et al.
    Cancer.Res., 2015;76:127
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