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XY 018

6223 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6223/50
6223/10
ROR/NR1F Antagonists Small Molecule
1 Image
Description: RORγ antagonist; inhibits AR expression

Chemical Name: N-[2'-Fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'biphenyl]-4-yl]-2-nitrobenzeneacetamide

Purity: ≥98%

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Biological Activity

RORγ antagonist (EC50 = 190 nM). Suppresses androgen receptor expression in prostate cancer cell lines. Also inhibits growth of tumors in androgen receptor-positive xenograft models.

Technical Data

M.Wt:
516.36
Formula:
C23H15F7N2O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1873358-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer.
    Wang et al.
    Nat.Med., 2016;22:488
  2. Re-emergence of an orphan therapeutic target for the treatment of resistant prostate cancer - a through conformational and binding analysis for RORγ protein.
    Ndagi et al.
    J.Biomol.Struct.Dyn., 2016;36:1

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