Home / ROR/NR1F Antagonists / XY 018

XY 018

Catalog #: 6223 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6223/50
6223/10
XY 018 | CAS No. 1873358-87-2 | ROR/NR1F Antagonists
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Description: RORγ antagonist; inhibits AR expression

Chemical Name: N-[2'-Fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'biphenyl]-4-yl]-2-nitrobenzeneacetamide

Purity: ≥98%

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Biological Activity

XY 018 is a RORγ antagonist (EC50 = 190 nM). Suppresses androgen receptor expression in prostate cancer cell lines. Also inhibits growth of tumors in androgen receptor-positive xenograft models.

Technical Data

M.Wt:
516.36
Formula:
C23H15F7N2O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1873358-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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