Selective estrogen receptor modulator (SERM) that displays selectivity for ERα
values are 0.09 and 11.31 nM respectively) and no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Acts as an agonist in the bone and antagonist in reproductive tissue. Suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells.
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All Tocris products are intended for laboratory research use only.
Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor α and their bioactivities in vivo.
Yang et al.
Biological activities of a novel selective oestrogen receptor modulator derived from raloxifene (Y134).
Ning et al.