Y-29794 oxalate

Key Product Details

Product Description

Y-29794 oxalate is a inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β-peptide. Potently inhibits rat brain prolyl endopeptidase (K_i = 0.95 nM) in vitro, and prevents amyloid β-peptide deposition in vivo. Orally active and brain penetrant.

Product Specifications for Y-29794 oxalate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Y-29794 oxalate

The following data is based on the product molecular weight 508.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.15 mM	13.11 mL	65.53 mL	131.06 mL
0.75 mM	2.62 mL	13.11 mL	26.21 mL
1.5 mM	1.31 mL	6.55 mL	13.11 mL
7.5 mM	0.26 mL	1.31 mL	2.62 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Nakajima Y-29794 - a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci.Lett. 1992 PMID: 1436628
• Kato Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J.Pharmacol.Exp.Ther. 1997 PMID: 9336340

Product Documents for Y-29794 oxalate