Inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β
-peptide. Potently inhibits rat brain prolyl endopeptidase (Ki
= 0.95 nM) in vitro
, and prevents amyloid β
-peptide deposition in vivo
. Orally active and brain penetrant.
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All Tocris products are intended for laboratory research use only.
Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse.
Kato et al.
Y-29794 - a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain.
Nakajima et al.