Y-29794 oxalate
Discontinued Product
Chemical Name: [2-[[8-(Dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienylmethanone oxalate
Purity: ≥96%
Biological Activity
Y-29794 oxalate is a inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β-peptide. Potently inhibits rat brain prolyl endopeptidase (Ki = 0.95 nM) in vitro, and prevents amyloid β-peptide deposition in vivo. Orally active and brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse.
Kato et al.
J.Pharmacol.Exp.Ther., 1997;283:328 -
Y-29794 - a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain.
Nakajima et al.
Neurosci.Lett., 1992;141:156
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