SIRT1 activator. Inhibits proliferation of breast cancer cell lines expressing mutant p53. Induces G2
/M cell cycle arrest and apoptosis in triple negative breast cancer cells (TNBCs) in vitro
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Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells.
Yi et al.
Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis.
Ponnusamy et al.