YK 3-237
Discontinued Product
Chemical Name: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid
Purity: ≥98%
Biological Activity
YK 3-237 is a SIRT1 activator. Inhibits proliferation of breast cancer cell lines expressing mutant p53. Induces G2/M cell cycle arrest and apoptosis in triple negative breast cancer cells (TNBCs) in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells.
Yi et al.
Oncotarget, 2013;4:984 -
Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis.
Ponnusamy et al.
J.Pharmacol.Exp.Ther, 2015;354:142
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