Chemical Name: 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide
Biological ActivityYM 155 is a survivin suppressor. Down-regulates survivin expression and sensitizes human NSCLC cell lines to radiation. Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Also induces apoptosis in TRAIL-resistant glioma cells in vitro. YM 155 is also an inhibitor of ILF3 (interleukin enhancer binding factor 3), an RNA-binding protein. It reduces thermal and mechanical hypersensitivity in a mice model of inflammatory pain.
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Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines.
Iwasa et al.
Clin.Cancer Res., 2008;14:6496
Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway.
Premkumar et al.
Citation for YM 155
The citations listed below are publications that use Tocris products. Selected citations for YM 155 include:
1 Citation: Showing 1 - 1
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model.
Authors: Serafini Et al.
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