YM 155

Key Product Details

Product Description

YM 155 is a survivin suppressor. Down-regulates survivin expression and sensitizes human NSCLC cell lines to radiation. Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Also induces apoptosis in TRAIL-resistant glioma cells in vitro. YM 155 is also an inhibitor of ILF3 (interleukin enhancer binding factor 3), an RNA-binding protein. It reduces thermal and mechanical hypersensitivity in a mice model of inflammatory pain.

Product Specifications for YM 155

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for YM 155

The following data is based on the product molecular weight 443.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.28 mL	22.56 mL
5 mM	0.45 mL	2.26 mL	4.51 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Premkumar Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway. J.Pharmacol.Exp.Ther. 2013 PMID: 23740602
• Serafini SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model. Sci.Signal. 2023 PMID: 37159520
• Iwasa Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin.Cancer Res. 2008 PMID: 18927289

Product Documents for YM 155