YM 155

Catalog # Availability Size / Price Qty
YM 155 | CAS No. 781661-94-7 | IAP Inhibitors
1 Image
Description: Survivin suppressor
Alternative Names: sepantronium bromide

Chemical Name: 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

YM 155 is a survivin suppressor. Down-regulates survivin expression and sensitizes human NSCLC cell lines to radiation. Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Also induces apoptosis in TRAIL-resistant glioma cells in vitro. YM 155 is also an inhibitor of ILF3 (interleukin enhancer binding factor 3), an RNA-binding protein. It reduces thermal and mechanical hypersensitivity in a mice model of inflammatory pain.

Technical Data

Soluble to 100 mM in water and to 20 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for YM 155

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