Inhibitor of the reverse mode of Na+
exchange (NCX). Potently inhibits Na+
values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+
transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.
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All Tocris products are intended for laboratory research use only.
Na+/Ca2+ exchange inhibitors: a new class of calcium regulators.
Iwamoto et al.
Cardiovasc.Hematol.Disord.Drug Targets, 2007;7:188
YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.
Iwamoto and Kita