YM 244769

Catalog # Availability Size / Price Qty
4544/10
4544/50
Cat.No. 4544 - YM 244769 | C26H22FN3O3.2HCl | CAS No. 837424-39-2
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Description: Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

Chemical Name: N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride

Purity: ≥99%

Product Details
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Biological Activity

Inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

Technical Data

M.Wt:
516.39
Formula:
C26H22FN3O3.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
837424-39-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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