YM 244769

Key Product Details

Product Description

YM 244769 is an inhibitor of the reverse mode of Na⁺/Ca²⁺ exchange (NCX). Potently inhibits Na⁺-dependent ⁴⁵Ca²⁺ uptake (IC₅₀ values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na⁺ and Ca²⁺ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

Product Specifications for YM 244769

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for YM 244769

The following data is based on the product molecular weight 516.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.68 mL	19.37 mL
5 mM	0.39 mL	1.94 mL	3.87 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

• Iwamoto and Kita YM-244769, a novel Na⁺/Ca²⁺ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol.Pharmacol. 2006 PMID: 16973719
• Iwamoto Na⁺/Ca²⁺ exchange inhibitors: a new class of calcium regulators. Cardiovasc.Hematol.Disord.Drug Targets 2007 PMID: 17896959

Product Documents for YM 244769