YM 244769
Chemical Name: N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
Purity: ≥99%
Biological Activity
Inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Na+/Ca2+ exchange inhibitors: a new class of calcium regulators.
Iwamoto et al.
Cardiovasc.Hematol.Disord.Drug Targets, 2007;7:188 -
YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.
Iwamoto and Kita
Mol.Pharmacol., 2006;70:2075
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Citation for YM 244769
The citations listed below are publications that use Tocris products. Selected citations for YM 244769 include:
1 Citation: Showing 1 - 1
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Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
Authors: O'Donnell Et al.
J Neurosci 2016;36:7109
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