Z 944

Catalog # Availability Size / Price Qty
6367/10
6367/50
Cat.No. 6367 - Z 944 | C19H27ClFN3O2 | CAS No. 1199236-64-0
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Description: Ca2+ channel blocker (T-type)

Chemical Name: 4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide

Purity: ≥98%

Product Details
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Biological Activity

Selective T-type Ca2+ channel blocker (IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo. Exhibits anti-seizure effects in animal models.

Technical Data

M.Wt:
383.89
Formula:
C19H27ClFN3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1199236-64-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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