Z 944

Catalog # Availability Size / Price Qty
Z 944 | CAS No. 1199236-64-0 | Voltage-gated Calcium Channel Blockers
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Description: CaV3.x blocker

Chemical Name: 4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide

Product Details

Biological Activity

Selective T-type Ca2+ channel blocker (IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo. Exhibits anti-seizure effects in animal models.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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