Catalog Number: 5630
Chemical Name: 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide
Biological Activity
Putative inhibitor of signal peptide peptidase; inhibits p-Prl signal peptide processing (IC50 = 50 nM). Exhibits no effect on signal peptidases or proteasome activity. Reduces HSV-1 replication in vitro and in vivo.
Technical Data
  • M.Wt:
    809
  • Formula:
    C43H64N6O9
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    313664-40-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor.
    Weihofen et al.
    J.Biol.Chem., 2000;275:30951
  2. Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo.
    Allen et al.
    Exp.Eye Res., 2014;123:8
  3. Targeting presenilin-type aspartic protease signal peptide peptidase with γ-secretase inhibitors.
    Weihofen et al.
    J.Biol.Chem., 2003;278:16528

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