(Z-LL)₂ ketone

Key Product Details

Product Description

Putative inhibitor of signal peptide peptidase; inhibits p-Prl signal peptide processing (IC₅₀ = 50 nM). Exhibits no effect on signal peptidases or proteasome activity. Reduces HSV-1 replication in vitro and in vivo.

Product Specifications for (Z-LL)₂ ketone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (Z-LL)₂ ketone

The following data is based on the product molecular weight 809.00.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	12.36 mL	61.80 mL	123.61 mL
0.5 mM	2.47 mL	12.36 mL	24.72 mL
1 mM	1.24 mL	6.18 mL	12.36 mL
5 mM	0.25 mL	1.24 mL	2.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Allen Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo. Exp.Eye Res. 2014 PMID: 24768597
• Weihofen Targeting presenilin-type aspartic protease signal peptide peptidase with γ-secretase inhibitors. J.Biol.Chem. 2003 PMID: 12621027
• Weihofen Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J.Biol.Chem. 2000 PMID: 10921927

Product Documents for (Z-LL)₂ ketone