Chemical Name: 5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide
Biological ActivityZeta-chain-associated protein kinase 70 (Zap70) inhibitor (IC50 = 1.8 μM in fluorescence polarization assay). Inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of inhibitors of the association of ZAP-70 with the T-cell receptor by high-throughput screen.
Visperas et al.
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