Catalog # Availability Size / Price Qty
Zardaverine | CAS No. 101975-10-4 | Phosphodiesterase Inhibitors
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Description: PDE3/4 inhibitor

Chemical Name: 6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone

Purity: ≥98%

Product Details
Citations (4)

Biological Activity

Zardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 μM respectively).

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J
    Nature, 2012;492(7427):123-7.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. Is phosphodiesterase inhibition a relevant bronchospasmolytic principle?
    Kilian et al.
    Agents Actions Suppl., 1989;28:331
  4. Actions of the phosphodiesterase inhibitor zardaverine on guinea pig ventricular muscle.
    Galvan and Schudt
    Naunyn Schmiedebergs Arch.Pharmacol., 1990;342:221

Product Datasheets

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Citations for Zardaverine

The citations listed below are publications that use Tocris products. Selected citations for Zardaverine include:

4 Citations: Showing 1 - 4


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