Catalog Number: 1046
Chemical Name: 6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone
Biological Activity
Phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 μM respectively). Also available as part of the Phosphodiesterase Inhibitor Tocriset™.
Technical Data
  • M.Wt:
    268.22
  • Formula:
    C12H10F2N2O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    101975-10-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Actions of the phosphodiesterase inhibitor zardaverine on guinea pig ventricular muscle.
    Galvan and Schudt
    Naunyn Schmiedebergs Arch.Pharmacol., 1990;342:221
  2. Is phosphodiesterase inhibition a relevant bronchospasmolytic principle?
    Kilian et al.
    Agents Actions Suppl., 1989;28:331
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Zardaverine include:

3 Citations: Showing 1 - 3
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  1. Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
    Authors: Navarro Et al.
    J Neurosci 2015;35:6639
  2. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature 2012;492:123
  3. Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea.
    Authors: Zerani Et al.
    Pain 2004;183:279

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