ZCL 278

Catalog # Availability Size / Price Qty
4794/10
4794/50
Cat.No. 4794 - ZCL 278 | C21H19BrClN5O4S2 | CAS No. 587841-73-4
1 Image
Description: Cdc42 inhibitor

Chemical Name: 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide

Purity: ≥95%

Product Details
Citations (4)
Reviews

Biological Activity

Selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.

Technical Data

M.Wt:
584.89
Formula:
C21H19BrClN5O4S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at +4°C
CAS No:
587841-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility.
    Friesland et al.
    Proc.Natl.Acad.Sci.USA, 2013;110:1261

Product Datasheets

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Citations for ZCL 278

The citations listed below are publications that use Tocris products. Selected citations for ZCL 278 include:

4 Citations: Showing 1 - 4

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