Catalog Number: 4794
Chemical Name: 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide
Biological Activity
Selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.
Technical Data
  • M.Wt:
    584.89
  • Formula:
    C21H19BrClN5O4S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Store at +4°C
  • CAS No:
    587841-73-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility.
    Friesland et al.
    Proc.Natl.Acad.Sci.USA, 2013;110:1261
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ZCL 278 include:

4 Citations: Showing 1 - 4
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  1. Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix
    Authors: Bijata Et al.
    Cell Rep 2017;19:1767
  2. Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons
    Authors: Speranza Et al.
    J Neurochem 2017;141:647
  3. Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics.
    Authors: Speranza Et al.
    Nat Biotechnol 2015;9:62
  4. Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro.
    Authors: Bijata Et al.
    Front Cell Neurosci 2015;9:199

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