Catalog Number: 4794
Chemical Name: 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide
Biological Activity
Selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility.
    Friesland et al.
    Proc.Natl.Acad.Sci.USA, 2013;110:1261

The citations listed below are publications that use Tocris products. Selected citations for ZCL 278 include:

Showing Results 1 - 2 of 2

  1. Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics.
    Authors: Speranza Et al.
    Nat Biotechnol
  2. Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro.
    Authors: Bijata Et al.
    Front Cell Neurosci
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