hh ZD 9379 (CAS 170142-20-8): R&D Systems
Catalog Number: 3322
Chemical Name: 7-Chloro-2,3-dihydro-2-(4-methoxy-2-methylphenyl)pyridazino [4,5-b] quinoline-1,4,10(5H)trione
Biological Activity
NMDA receptor antagonist; acts at glycine site. Neuroprotective; reduces infarct size and frequency of spreading depressions in a rat model of ischemic stroke. Brain penetrant.
Technical Data
  • M.Wt:
    383.79
  • Formula:
    C19H14ClN3O4
  • Solubility:
    Soluble to 50 mM in DMSO and to 20 mM in 1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    170142-20-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca
Background References
  1. Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies.
    Takano
    Stroke., 1997;28:1255
  2. A glycine antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion.
    Tatlisumak
    Acta.Neurochir.Suppl., 2000;76:331
  3. Pyridazino[4,5-b]quinolinediones: a series of novel glycine site NMDA antagonists with potent in vitro and in vivo properties.
    Bare
    Abstracts of Papers of the ACS, 1993;205:79. Abstract.

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