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ZD 9379

3322 Datasheet / COA / SDS
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3322/10
ZD 9379 | CAS No. 170142-20-8 | NMDA Receptor Antagonists
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Description: Brain penetrant NMDA antagonist; acts at glycine site

Chemical Name: 7-Chloro-2,3-dihydro-2-(4-methoxy-2-methylphenyl)pyridazino [4,5-b] quinoline-1,4,10(5H)trione

Purity: ≥98%

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Biological Activity

NMDA receptor antagonist; acts at glycine site. Neuroprotective; reduces infarct size and frequency of spreading depressions in a rat model of ischemic stroke. Brain penetrant.

Technical Data

M.Wt:
383.79
Formula:
C19H14ClN3O4
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in 1eq. NaOH
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
170142-20-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca

Background References

  1. Pyridazino[4,5-b]quinolinediones: a series of novel glycine site NMDA antagonists with potent in vitro and in vivo properties.
    Bare
    Abstracts of Papers of the ACS, 1993;205:79. Abstract.
  2. Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies.
    Takano
    Stroke., 1997;28:1255
  3. A glycine antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion.
    Tatlisumak
    Acta.Neurochir.Suppl., 2000;76:331

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