ZD 9379
Chemical Name: 7-Chloro-2,3-dihydro-2-(4-methoxy-2-methylphenyl)pyridazino [4,5-b] quinoline-1,4,10(5H)trione
Purity: ≥98%
Biological Activity
NMDA receptor antagonist; acts at glycine site. Neuroprotective; reduces infarct size and frequency of spreading depressions in a rat model of ischemic stroke. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Pyridazino[4,5-b]quinolinediones: a series of novel glycine site NMDA antagonists with potent in vitro and in vivo properties.
Bare
Abstracts of Papers of the ACS, 1993;205:79. Abstract. -
Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies.
Takano
Stroke., 1997;28:1255 -
A glycine antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion.
Tatlisumak
Acta.Neurochir.Suppl., 2000;76:331
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