Biological ActivityZIP is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
(Modifications: Ser-1 = Myr-Ser)
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Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation.
Serrano et al.
Storage of spatial information by the maintenance mechanism of LTP.
Pastalkova et al.
Protein kinase Mz is necessary and sufficient for LTP maintenance.
Ling et al.
Nature Neurosci., 2002;5:295
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