Catalog Number: 2549
Alternate Names: z-Pseudosubstrate inhibitory peptide
Biological Activity
Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Control and biotinylated peptides (Cat. Nos. 3215 and 3290) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Ser-1 = Myr-Ser)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation.
    Serrano et al.
    J.Neurosci., 2005;25:1979
  2. Storage of spatial information by the maintenance mechanism of LTP.
    Pastalkova et al.
    Science, 2006;313:1141
  3. Protein kinase Mz is necessary and sufficient for LTP maintenance.
    Ling et al.
    Nature Neurosci., 2002;5:295
Tocris Peptides
Description Application Cat# Citations Images  

ZIP (Scrambled)

3215 2  
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ZIP, Biotinylated

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