Biological ActivityZIP is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
(Modifications: Ser-1 = Myr-Ser)
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Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation.
Serrano et al.
Storage of spatial information by the maintenance mechanism of LTP.
Pastalkova et al.
Protein kinase Mz is necessary and sufficient for LTP maintenance.
Ling et al.
Nature Neurosci., 2002;5:295
Citations for ZIP
The citations listed below are publications that use Tocris products. Selected citations for ZIP include:
8 Citations: Showing 1 - 8
Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix.
Authors: Balaban Et al.
Front Cell Neurosci ;9:222
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Authors: Awasthi Et al.
Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment.
Authors: Mirza Et al.
JCI Insight 2017;2
The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli.
Authors: Grosso Et al.
Nat Commun 2015;6:8886
Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury.
Authors: Han Et al.
J Neurophysiol 2015;2015:601767
Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity.
Authors: Chen Et al.
Mol Pain 2015;113:3047
Prkcz null mice show normal learning and memory.
Authors: Lee Et al.
PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain.
Authors: Laferrière Et al.
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