ZIP

Catalog # Availability Size / Price Qty
2549/1
ZIP
1 Image
Description: Cell-permeable inhibitor of atypical PKC isozyme PKMζ
Alternative Names: z-Pseudosubstrate inhibitory peptide
Product Details
Citations (8)
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Reviews

Biological Activity

Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Control Peptide and Biotinylated Peptide also available.

Technical Data

M.Wt:
1928.4
Formula:
C90H154N30O17
Sequence:
SIYRRGARRWRKL

(Modifications: Ser-1 = Myr-Ser)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
863987-12-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation.
    Serrano et al.
    J.Neurosci., 2005;25:1979
  2. Storage of spatial information by the maintenance mechanism of LTP.
    Pastalkova et al.
    Science, 2006;313:1141
  3. Protein kinase Mz is necessary and sufficient for LTP maintenance.
    Ling et al.
    Nature Neurosci., 2002;5:295

Product Datasheets

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