Catalog Number: 2549
Alternate Names: z-Pseudosubstrate inhibitory peptide
Biological Activity
Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Control and biotinylated peptides (Cat. Nos. 3215 and 3290) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Ser-1 = Myr-Ser)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation.
    Serrano et al.
    J.Neurosci., 2005;25:1979
  2. Storage of spatial information by the maintenance mechanism of LTP.
    Pastalkova et al.
    Science, 2006;313:1141
  3. Protein kinase Mz is necessary and sufficient for LTP maintenance.
    Ling et al.
    Nature Neurosci., 2002;5:295

The citations listed below are publications that use Tocris products. Selected citations for ZIP include:

5 Citations: Showing 1 - 5
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  1. Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix.
    Authors: Balaban Et al.
    Front Cell Neurosci ;9:222
  2. Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury.
    Authors: Han Et al.
    J Neurophysiol 2015;2015:601767
  3. Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity.
    Authors: Chen Et al.
    Mol Pain 2015;113:3047
  4. Prkcz null mice show normal learning and memory.
    Authors: Lee Et al.
    Nature 2013;493:416
  5. PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain.
    Authors: Laferrière Et al.
    Autophagy 2011;7:99
Tocris Peptides
Description Application Cat# Citations Images  

ZIP (Scrambled)

3215 2  
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ZIP, Biotinylated

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