ZIP

  ( 6 citations )    
Product Datasheet
Catalog Number:2549
Alternate Names:z-Pseudosubstrate inhibitory peptide
Chemical Name:
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Control Peptide and Biotinylated Peptide also available.

Technical Data
  • M.Wt:
    1982.4
  • Formula:
    C90H154N30O17
  • Sequence:
    SIYRRGARRWRKL

    (Modifications: Ser-1 = Myr-Ser)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    863987-12-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for ZIP include:

6 Citations: Showing 1 - 6
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  1. Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix.
    Authors: Balaban Et al.
    Front Cell Neurosci  ;9:222
  2. The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli.
    Authors: Grosso Et al.
    Nat Commun  2015;6:8886
  3. Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury.
    Authors: Han Et al.
    J Neurophysiol  2015;2015:601767
  4. Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity.
    Authors: Chen Et al.
    Mol Pain  2015;113:3047
  5. Prkcz null mice show normal learning and memory.
    Authors: Lee Et al.
    Nature  2013;493:416
  6. PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain.
    Authors: Laferrière Et al.
    Autophagy  2011;7:99

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