ZM 323881 hydrochloride

  ( 8 citations )    
Product Datasheet
Catalog Number:2475
Chemical Name:5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride
Product Details
Citations (8)
Supplemental Products
Reviews
Biological Activity
Potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC50 > 50 μM). Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM).
Technical Data
  • M.Wt:
    411.86
  • Formula:
    C22H18FN3O2.HCl
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    193000-39-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for ZM 323881 hydrochloride include:

8 Citations: Showing 1 - 8
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  1. The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain.
    Authors: Hulse Et al.
    Neurobiol Dis  2016;96:186
  2. Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis.
    Authors: Maertens Et al.
    Arterioscler Thromb Vasc Biol  2014;9:e106976
  3. Investigation of a novel molecular descriptor for the lead optimization of 4-aminoquinazolines as vascular endothelial growth factor receptor-2 inhibitors: application for quantitative structure-activity relationship analysis in lead optimization.
    Authors: Kawakami Et al.
    PLoS One  2011;21:1371
  4. Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity.
    Authors: Zhong Et al.
    Cell Res  2011;21:1080
  5. Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ?.
    Authors: Lakshmikanthan Et al.
    Blood  2011;118:2015
  6. VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta.
    Authors: Holmes Et al.
    PLoS One  2010;5:e11435
  7. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
    Authors: Huang Et al.
    J Neurosci  2010;30:6080
  8. Synergistic induction of mitogen-activated protein kinase phosphatase-1 by thrombin and epidermal growth factor requires vascular endothelial growth factor receptor-2.
    Authors: Chandrasekharan Et al.
    Biomed Rep  2010;30:1983

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