ZM 323881 hydrochloride
Chemical Name: 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride
Biological ActivityZM 323881 hydrochloride is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC50 > 50 μM). Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity.
Whittles et al.
Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF.
Endo et al.
J.Recept.Signal Transduct.Res., 2003;23:239
Citations for ZM 323881 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ZM 323881 hydrochloride include:
11 Citations: Showing 1 - 10
Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis.
Authors: Page Et al.
Cell Rep 2019;27:3139
uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.
Authors: Durré Et al.
Nat Commun 2018;9:5178
Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor.
Authors: Busceti Et al.
Front Cell Neurosci 2018;12:292
The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain.
Authors: Hulse Et al.
Neurobiol Dis 2016;96:186
Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis.
Authors: Maertens Et al.
Arterioscler Thromb Vasc Biol 2014;9:e106976
Investigation of a novel molecular descriptor for the lead optimization of 4-aminoquinazolines as vascular endothelial growth factor receptor-2 inhibitors: application for quantitative structure-activity relationship analysis in lead optimization.
Authors: Kawakami Et al.
PLoS One 2011;21:1371
Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity.
Authors: Zhong Et al.
Cell Res 2011;21:1080
Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ?.
Authors: Lakshmikanthan Et al.
VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta.
Authors: Holmes Et al.
PLoS One 2010;5:e11435
Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
Authors: Huang Et al.
J Neurosci 2010;30:6080
Synergistic induction of mitogen-activated protein kinase phosphatase-1 by thrombin and epidermal growth factor requires vascular endothelial growth factor receptor-2.
Authors: Chandrasekharan Et al.
Biomed Rep 2010;30:1983
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