ZM 323881 hydrochloride

Key Product Details

Product Description

ZM 323881 hydrochloride is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC₅₀ = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC₅₀ > 50 μM). Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC₅₀ = 8 nM).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications for ZM 323881 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ZM 323881 hydrochloride

The following data is based on the product molecular weight 411.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.86 mL	24.28 mL	48.56 mL
2.5 mM	0.97 mL	4.86 mL	9.71 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
25 mM	0.10 mL	0.49 mL	0.97 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Endo Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J.Recept.Signal Transduct.Res. 2003 PMID: 14626450
• Whittles ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation 2002 PMID: 12483548

Product Documents for ZM 323881 hydrochloride