Potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC50
= 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ
, FGFR1, EGFR and erbB2 (IC50
> 50 μ
M). Inhibits VEGF-A-induced endothelial cell proliferation in vitro
= 8 nM).
Soluble to 50 mM in DMSO
Desiccate at +4°C
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Sold with the permission of AstraZeneca UK Ltd.
ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity.
Whittles et al.
Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF.
Endo et al.
J.Recept.Signal Transduct.Res., 2003;23:239
The citations listed below are publications that use Tocris products. Selected citations for ZM 323881 hydrochloride include:
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