Catalog Number: 6111
Alternate Names: Zometa
Chemical Name: [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
Biological Activity
Potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in 1.1eq. NaOH and to 3 mM in water
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.
    Dunford et al.
    J.Pharmacol.Exp.Ther., 2001;296:235
  2. Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB.
    Schech et al.
    Mol.Cancer Ther., 2013;12:1356
  3. Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro.
    Tassone et al.
    Br.J.Cancer, 2003;88:1971
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