Zoledronic Acid

Catalog Number:6111
Alternate Names:Zometa
Chemical Name:[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
Product Details
Biological Activity
Potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in 1.1eq. NaOH and to 3 mM in water
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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