Zoledronic Acid

Catalog # Availability Size / Price Qty
6111/10
6111/50

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Zoledronic Acid | CAS No. 118072-93-8 | Ras GTPase Inhibitors
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Description: Potent farnesyl diphosphate (FPP) synthase inhibitor
Alternative Names: Zometa

Chemical Name: [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid

Purity: ≥98%

Product Details
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Biological Activity

Zoledronic Acid is a potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.

Technical Data

M.Wt:
272.09
Formula:
C5H10N2O7P2
Solubility:
Soluble to 50 mM in 1.1eq. NaOH and to 3 mM in water
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
118072-93-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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