Chemical Name:[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
Biological Activity Potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.
Soluble to 50 mM in 1.1eq. NaOH and to 3 mM in water
Store at +4°C
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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