Chemical Name: (4S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone
Biological ActivityZolmitriptan is a potent 5-HT1B/1D/1F agonist (Ki values are 0.63, 5.01 and 63.09 nM for h5-HT1D, h5-HT1B and h5-HT1F receptors respectively). Inhibits trigeminal nerve stimulation-mediated neurogenic plasma protein extravasation in guinea pigs; blocks long excitatory postsynaptic potentials (EPSPs) in a rat model of spinal cord injury.
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Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan).
Martin et al.
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Murray et al.
How efficacious are 5-HT1B/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines.
Pauwels et al.
Citation for Zolmitriptan
The citations listed below are publications that use Tocris products. Selected citations for Zolmitriptan include:
1 Citation: Showing 1 - 1
Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay.
Authors: Gadgaard & Jensen
Biochem Pharmacol 2020;175
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