Catalog Number: 2625
Alternate Names: AD 810, CI 912
Chemical Name: 1,2-Benzisoxazole-3-methanesulfonamide
Biological Activity
Antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in rats.
    Tokumaru et al.
    Neurochem.Res., 2000;25:1107
  2. Zonisamide: a new antiepileptic drug.
    Sobieszek et al.
    Pol.J.Pharmacol., 2003;55:683
  3. Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity.
    Gluck et al.
    J.Neural Transm., 2004;111:713
  4. Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells.
    Huang et al.
    J.Pharmacol.Exp.Ther., 2007;321:98

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