Chemical Name: 1,2-Benzisoxazole-3-methanesulfonamide
Biological ActivityZonisamide is a antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.
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Zonisamide: a new antiepileptic drug.
Sobieszek et al.
Novel DA releasing response of an anti-convulsant agent with possible anti-Parkinson's activity.
Gluck et al.
J.Neural Transm., 2004;111:713
Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells.
Huang et al.
In vivo evaluation of hippocampal anti-oxidant ability of zonis. in rats.
Tokumaru et al.
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Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities at increasing concentrations.We aimed to decrease calcium conductance through the channels as increase leads to increased depolarization and excitability.