Chemical Name: 1,2-Benzisoxazole-3-methanesulfonamide
Biological ActivityZonisamide is a antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Zonisamide: a new antiepileptic drug.
Sobieszek et al.
Novel DA releasing response of an anti-convulsant agent with possible anti-Parkinson's activity.
Gluck et al.
J.Neural Transm., 2004;111:713
Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells.
Huang et al.
In vivo evaluation of hippocampal anti-oxidant ability of zonis. in rats.
Tokumaru et al.
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