Zonisamide

Tocris Bioscience | Catalog # 2625

Blocks voltage-sensitive Na+ and Ca2+ channels (T-type)
Tocris Bioscience

Key Product Details

Description

Blocks voltage-sensitive Na+ and Ca2+ channels (T-type)

Alternative Names

AD 810,CI 912
View all Ion Channel Modulators »

Product Description

Zonisamide is a antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.

Product Specifications for Zonisamide

Molecular Weight

212.22

Formula

C8H8N2O3S

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

1,2-Benzisoxazole-3-methanesulfonamide

CAS Number

68291-97-4

PubChem ID

5734

InChI Key

UBQNRHZMVUUOMG-UHFFFAOYSA-N

SMILES

NS(=O)(=O)CC1=NOC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.12 10
DMSO 21.22 100

Preparing Stock Solutions for Zonisamide

The following data is based on the product molecular weight 212.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.71 mL 23.56 mL 47.12 mL
5 mM 0.94 mL 4.71 mL 9.42 mL
10 mM 0.47 mL 2.36 mL 4.71 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for Zonisamide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Zonisamide

For research use only

Customer Reviews for Zonisamide (1)

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  • Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/27/2019
    Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities at increasing concentrations.We aimed to decrease calcium conductance through the channels as increase leads to increased depolarization and excitability.
    Zonisamide 2625

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