ZYS 1

Key Product Details

Product Description

ZYS 1 is an ADAR1 (adenosine deaminase acting on RNA 1) deaminase inhibitor (IC₅₀ = 946 nM). In vitro, ZYS 1 exhibits antiproliferative activity against multiple prostate cancer cell lines. In vivo, ZYS 1 displays antitumor efficacy in prostate cancer cell-derived xenograft mouse model (20 mg and 40 mg per kg (body weight) intraperitoneally, with tumor growth inhibition rates of 66.68% and 81.83%, respectively).

Product Specifications for ZYS 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ZYS 1

The following data is based on the product molecular weight 303.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.29 mL	16.46 mL	32.93 mL
5 mM	0.66 mL	3.29 mL	6.59 mL
10 mM	0.33 mL	1.65 mL	3.29 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wang Targeting ADAR1 with a small molecule for the treatment of prostate cancer. Nat.Cancer 2025 PMID: 39930013

Product Documents for ZYS 1