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ZYS 1

Catalog #: 8921 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8921/10
8921/50

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ZYS 1 | CAS No. 2734853-80-4 | Deaminase Inhibitors
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Description: ADAR1 (adenosine deaminase acting on RNA 1) deaminase inhibitor

Chemical Name: 5'-Chloro-5'-deoxy-2-fluoroadenosine

Purity: ≥98%

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Biological Activity

ZYS 1 is an ADAR1 (adenosine deaminase acting on RNA 1) deaminase inhibitor (IC50 = 946 nM). In vitro, ZYS 1 exhibits antiproliferative activity against multiple prostate cancer cell lines. In vivo, ZYS 1 displays antitumor efficacy in prostate cancer cell-derived xenograft mouse model (20 mg and 40 mg per kg (body weight) intraperitoneally, with tumor growth inhibition rates of 66.68% and 81.83%, respectively).

Technical Data

M.Wt:
303.68
Formula:
C10H11ClFN5O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2734853-80-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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