Show Categories

Macrophage - Common Markers

The common markers used for distinguishing macrophages from other immune cell types are listed below or view additional markers that can be used to identify different macrophage activation states.

Property title
B7-1/CD80
B7-1/CD80
ProductsClose
B7-2/CD86
B7-2/CD86
ProductsClose
CCR5
CCR5
ProductsClose
CD11b/Integrin alpha M
CD11b/Integrin alpha M
CD11c
CD11c
ProductsClose
CD14
CD14
ProductsClose
CD15 (SSEA-1)/Lewis X
CD15 (SSEA-1)/Lewis X
ProductsClose
CD68/SR-D1
CD68/SR-D1
ProductsClose
CD163
CD163
ProductsClose
EMR1 (human)
EMR1 (human)
ProductsClose
F4/80 (mouse)
F4/80 (mouse)
ProductsClose
Fc gamma RI/CD64
Fc gamma RI/CD64
Fc gamma RII/CD32
Fc gamma RII/CD32
Fc gamma RIII/CD16
Fc gamma RIII/CD16
Galectin-3
Galectin-3
ProductsClose
GITR Ligand
GITR Ligand
ProductsClose
HLA-DR
HLA-DR
ProductsClose
Integrin alpha L/CD11a
Integrin alpha L/CD11a
LAMP-2/CD107b
LAMP-2/CD107b
LILRB4/CD85k/ILT3
LILRB4/CD85k/ILT3
M-CSF R/CD115
M-CSF R/CD115
MHC class II
MHC class II
Siglec-3/CD33
Siglec-3/CD33
ProductsClose
TLR2
TLR2
ProductsClose
TLR4
TLR4
ProductsClose
Cell Surface Markers
Cell Surface Markers

Overview

Macrophages are specialized innate immune cells capable of phagocytosis and antigen presentation. They reside in all tissues of the body and are involved in immune surveillance, initiation of immune responses, and maintenance of tissue integrity. In addition, they may have specialized functions depending on their tissue of residence. Macrophages located in different tissues exhibit phenotypic heterogeneity in terms of both the cell surface receptors and transcription factors that they express. In addition, they are remarkably versatile and can rapidly alter their phenotypes and functions in response to environmental signals. Common cell surface markers used to identify human and mouse macrophages include CD11b/Integrin alpha M, CD14, CD68, Fc gamma RIII/CD16, Fc gamma RI/CD64, and CCR5, along with F4/80 in mouse. Additional markers are used to identify specific tissue-resident macrophages and different macrophage activation states.