Chemokine Nomenclature

Contents

• C Family
• CX₃C Family
• CC Family
• CXC Family
• References

NOTE: Alternate names shown in BOLD represent the most commonly recognized name. Receptors shown in BOLD are referenced in Zlotnik A. & O. Yoshie (2012). Additional studies have demonstrated chemokine ligand binding to additional chemokine receptor family members (See References). Those receptors are also included here but are not shown in bold.

Footnotes

1. Following in-depth genome analysis, it has been determined that the gene product encoded by mouse Ccl6 is homologous to human CCL23.
2. Mouse CCL8 is not the human CCL8 ortholog but is instead a mouse-specific chemokine.
3. Mouse CCL9 was found to be equivalent to mouse CCL10. Additionally, following in-depth genome analysis, it has been determined that the gene product encoded by mouse Ccl9 is homologous to human CCL15.
4. This gene is not expressed.
5. Following in-depth genome analysis, it has been determined that the gene product encoded by mouse Cxcl3 is homologous to human CXCL1, and the gene product encoded by mouse Cxcl1 is homologous to human CXCL3.
6. Zlotnik, A. & O. Yoshie (2012) suggests that following in-depth genome analysis, the gene product encoded by mouse Cxcl5 is homologous to human CXCL6. However, a consensus is emerging in the field that the mouse Cxcl5 gene encoding the LIX protein is a rodent-specific chemokine and does not have a pure human ortholog.

References

1. Zlotnik, A. & O. Yoshie (2012) Immunity 36:705.
2. Zlotnik, A. & O. Yoshie (2000) Immunity 12:121.
3. Hansell, C.A. et al. (2011) Immunol. Cell Biol. 89:197.
4. Gosling, J. et al. (2000) J. Immunol. 164:2851.
5. Balkwill, F. (2004) Nat. Rev. Cancer 4:540.
6. Schweickart, V.L. et al. (2000) J. Biol. Chem. 275:9550.
7. Leick, M. et al. (2010) Immunology 129:536.
8. Lasagni, L. et al. (2003) J. Exp. Med. 197:1537.
9. Houshmand, P. & A. Zlotnik (2003) Curr. Opin. Chem. Biol. 7:457.
10. Moore, B. et al. (2006) Am. J. Respir. Cell Mol. Biol. 35:175.
11. Elsner, J. et al. (2005) Allergy 60:1386.
12. Vandercappellen, J. et al. (2011) Cytokine Growth Factor Rev. 22:1.
13. Howard, O.M.Z. et al. (2004) Biochem. Biophys. Res. Commun. 320:927.
14. Struyf, S. et al. (2001) Eur. J. Immunol. 31:2170.
15. Islam, S.A. et al. (2013) J. Exp. Med. 210:1889.

Related Information

• Chemokine Superfamily Pathway
• Chemokine Receptor Intracellular Signaling
• Chemokines and Receptors
• Mini-review: Chemokines I
• Mini-review: Chemokines III