Additional 5-HT3 Receptor Compounds

Serotonin 5-HT₃ receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of 4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT₃ receptor subtypes have been identified (5-HT_3A-E).

The 5-HT_3B-E subtypes do not form functional homo-oligomeric complexes like the 5-HT_3A subtypes, but co-assemble with 5-HT_3A to influence its functional expression.