Adenosine A3 Receptor Inverse Agonists

The adenosine A₃ receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A₁, A_2A and A_2B. They display high expression levels in the testes and mast cells of rats, with low expression levels in the thyroid, liver, kidney, heart, intestine and most brain areas. Adenosine A₃ receptors play a role in mast cell degranulation, coronary vasodilation and protection from reperfusion. The human A₃ receptor gene is localized on chromosome 1 (1p21-p13).