AMPA Receptor Blockers Small Molecules and Peptides

AMPA receptors are cation-permeable, ligand-gated ion channels. Like other members of this family, AMPA receptors are named based on a compound that was found to be selective for these receptors; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA). They consist of GluA1-4 subunits that assemble as homomers or heteromers to form functional receptors. Each subunit is encoded by a different gene, and alternative versions of the subunits may be produced by gene splicing. There is a ...