2 results for "BMI-1 Small Molecules and Peptides" in Products
BMI-1 Small Molecules and Peptides
BMI-1 is a highly conserved class II member of the Polycomb group of genes which regulate diverse aspects of transcription, stem cell maintenance, cell proliferation, and oncogenesis. BMI-1 is a critical component of the large multimeric PRC1 complex that silences the transcription of many target genes. BMI-1 is highly conserved between species.
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
| Chemical Name: | 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione |
| Purity: | ≥98% |
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PRC1 Degrader (PROTAC®); degrades BMI1 and RING1B
| Chemical Name: | (2S,4R)-1-((S)-2-(7-(5-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl)piperazin-1-yl)pentanamido)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride |
| Purity: | ≥97% |
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