Cerebellin-1 Proteins and Enzymes

Cerebellin-1 (CBLN1) is a 35 kDa secreted glycoprotein in the Cerebellin family of TNF superfamily molecules. Cerebellins contain an N-terminal collagenous domain and a C-terminal TNF/C1q-like domain. Cerebellin-1 is expressed in the cerebellum, the parafascicular nucleus of the thalamus, and in the adrenal cortex and pancreatic islets. Cerebellin-1 forms noncovalent homotrimers that are disulfide-linked into hexamers. It can also form hetero-oligomers with Cerebellins-2, -3, and -4. ...