Compounds for HSC Proliferation and Renewal

Hematopoietic stem cells (HSCs) reside in the bone marrow and generate two progenitor cell lineages: myeloid and lymphoid cells. The myeloid cells include erythrocytes, platelets, neutrophils, basophils, eosinophils, monocytes/ macrophages, and dendritic cells. The lymphoid cells comprise natural killer cells, B and T lymphocytes.

Figure 1: Model of the hematopoietic hierarchy. HSCs have the potential to both self-renew and differentiate. Multipotent progenitors give rise to all ...