Chemical Name: (2R)-2-(Acetylamino)-3-mercaptopropanamide
Biological ActivityGlutathione (GSH) precursor and cell permeable antioxidant. Improves neuronal mitochondrial bioenergetics, reduces tissue damage and enhances functional recovery following spinal cord injury in rats. Also enhances behavioral recovery in rats following traumatic brain injury. Neuroprotective.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma.
Patel et al.
N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI.
Pandya et al.
Citation for N-Acetylcysteine amide
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HL-1 cardiomyocytes were pre-treated with Pyrrolidinedithiocarbamate (PDTC, 1 mM), Tempol (1 mM) or N-Acetylcysteine (NAC, 1 mM) for 30 min and stimulated with HOCl-LDL (200 µg/ml) for 2 h to follow CaMKII oxidation using Western blot.