Chemical Name: (2R)-2-(Acetylamino)-3-mercaptopropanamide
Biological ActivityN-Acetylcysteine amide is a glutathione (GSH) precursor and cell-permeable antioxidant. N-Acetylcysteine amide replenishes intracellular Glutathione (GSH). N-Acetylcysteine amide directly reduces intracellular Glutathione disulfide (GSSG) to GSH without glutathione peroxidase. N-Acetylcysteine amide has anti-inflammatory activity through regulation of activation of NF-κB and HIF-1α, as well as modulation of reactive oxygen species. N-Acetylcysteine amide improves neuronal mitochondrial bioenergetics, reduces tissue damage and enhances functional recovery following spinal cord injury in rats. N-Acetylcysteine amide also enhances behavioral recovery in rats following traumatic brain injury. Neuroprotective.
For more information about how N-Acetylcysteine amide may be used, see our protocol: 3D Culture of Lung Alveolar Cells
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Tocris products are intended for laboratory research use only, unless stated otherwise.
N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma.
Patel et al.
N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI.
Pandya et al.
Citations for N-Acetylcysteine amide
The citations listed below are publications that use Tocris products. Selected citations for N-Acetylcysteine amide include:
2 Citations: Showing 1 - 2
Microengineered multi-organoid system from hiPSCs to recapitulate human liver-islet axis in normal and type 2 diabetes.
Authors: Tao Et al.
The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.
Authors: Gutierrez Et al.
J Biol Chem 2014;289:33568
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HL-1 cardiomyocytes were pre-treated with Pyrrolidinedithiocarbamate (PDTC, 1 mM), Tempol (1 mM) or N-Acetylcysteine (NAC, 1 mM) for 30 min and stimulated with HOCl-LDL (200 µg/ml) for 2 h to follow CaMKII oxidation using Western blot.