CTRP3/C1qTNF3/CORS26 Proteins and Enzymes

C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher order molecular forms. C1qTNF3, also known as CTRP3 and CORS26, is predominantly expressed in cartilage and is induced in mature adipocytes.