DMRT2 Proteins and Enzymes

DMRT2, also known as Doublesex and mab-3-related transcription factor 2, consists of a 61.8 kDa, a 24.5 kDa, and a 36.9 kDa isoform and is involved in regulating activation of the gene MYF5 as a transcription factor during embryogenesis and somite development. Current research has linked the protein to diseases such as sex reversal, attention deficit hyperactivity disorder, leukemia, anemia, and gonadal dysgenesis. The protein interacts with UBC, CCDC18, BCLAF1, RPS3, and MYBBP1A in transcription pathways.