Glypican 4 Proteins and Enzymes

Glypican 4, also known as K-Glypican, is an approximately 220 kDa GPI-anchored heparan sulfate proteoglycan with a 60 kDa protein core. It is expressed in brain, kidney, adrenal gland, and fat tissue and binds to FGF basic. In the developing brain, Glypican 4 is found in lateral ventricles surrounding the telencephalon, the dentate gyrus, proliferating neuroepithelial cells, and neural precursors. It inhibits the dopaminergic differentiation of neurons. A 30 kDa cleaved ...