Guanylyl Cyclase F/GUCY2F Proteins and Enzymes

The GUCY2F gene encodes a retinal guanylyl cyclase 2 single-pass type 1 membrane protein that plays a significant functional role in the rods and cones of photoreceptors. Its coded proteins are 1,108 amino acids long at a mass of approximately 124 kDA. It is thought to be involved in the resynthesis of cGMP which is required for recovery of a dark state after light activation of the visual signal transduction cascade (phototransduction). The GUCY2F gene participates is purine metabolism, relaxin pathway, phototransduction, and the CRHR pathway. Its known to interact with various genes such as GUCA1B, GUCA1A, GUCA1C, PDE11A, and PDE4A.