HCN Channel Inhibitors

HCN (hyperpolarization-activated, cyclic nucleotide-gated) channels are members of the cyclic nucleotide-regulated channel family along with cyclic nucleotide-gated (CNG) channels. Each channel is made up of four subunits, with each subunit comprising six transmembrane α-helical segments, with the S4 segment thought to be the voltage sensor. They are cation permeable channels that open under hyperpolarization. In contrast to most voltage-gated ion channels, they are constitutively open at ...