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RO-275

Catalog #: 8977 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8977/50
8977/10

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RO-275 | CAS No. 2648837-04-9 | Ion Channel Modulators
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Description: Potent and selective HCN1 inhibitor

Chemical Name: 4-((2-Chloro-3-methylpyridin-4-yl)ethynyl)-5-methyl-1-(pyridin-3-yl)-1H-imidazole-2-carboxamide

Purity: ≥98%

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Biological Activity

RO-275 is a potent and selective HCN1 (hyperpolarization-activated cyclic-nucleotide-gated channel 1) inhibitor (IC50 = 46 nM). It shows <100-fold selectivity over HCN2, HCN3 and HCN4. In vivo, RO-275 improves performance in a translationally relevant touchscreen task of working memory (TUNL) in rats. RO-275 is orally bioavailable and brain-penetrant.

Technical Data

M.Wt:
351.79
Formula:
C18H14ClN5O
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2648837-04-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the RO-275 probe summary on the SGC website.

Product Datasheets

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