Hepassocin/FGL1 Proteins and Enzymes

Hepassocin, also known as fibrinogen like 1 (FGL1) and hepatocyte-derived fibrinogen-related protein 1 (HFREP1), is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. Hepassocin/FGL1 may play a role in the development of hepatocellular carcinomas. Hepassocin/FGL1 is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin/FGL1 is upregulated during liver regeneration following partial hepatectomy.