IBSP/Sialoprotein II Proteins and Enzymes

IBSP (integrin-binding sialoprotein; also BSP or bone sialoprotein II) is a 55 - 75 kDa, secreted, variably glycosylated, monomeric noncollagenous member of the SIBLING family of extracellular matrix (ECM) proteins. It is principally associated with the early stages of bone mineralization. IBSP is synthesized as a 317 amino acid (aa) precursor that contains a 16 aa signal sequence and a 301 aa mature region. The mature segment is divided into a basic N-terminus (aa 17 - 62), a central region ...