Na+/H+ Exchanger Inhibitors

Sodium-hydrogen exchangers (Na⁺/H⁺ exchangers, NHE) are ATP-independent membrane glycoprotein transporters that are involved in the regulation of intracellular pH, cell volume and the cellular response to hormones and mitogens. The transporters mediate the simultaneous efflux of a hydrogen ion and the influx of a sodium ion across the plasma membrane, the driving force being the inwardly directed electrochemical Na⁺ gradient. There are nine known mammalian NHE isoforms (NHE1-9), all of which ...