Chemical Name: [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride
Biological ActivityZoniporide dihydrochloride is a sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo.
Knight et al.
Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1.
Marala et al.
Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform-1, in an experimental model of cardiopulmonary bypass.
Clements-Jewery et al.
Citations for Zoniporide dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Zoniporide dihydrochloride include:
2 Citations: Showing 1 - 2
NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity.
Authors: Féraille Et al.
PLoS One 2014;9:e87239
The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells.
Authors: Goldman Et al.
PLoS One 2011;6:e23835
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