Zoniporide dihydrochloride

Catalog # Availability Size / Price Qty
2727/10
2727/50
Zoniporide dihydrochloride | CAS No. 241799-10-0 | Na+/H+ Exchanger Inhibitors
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Description: Selective NHE1 inhibitor
Alternative Names: CP 597396

Chemical Name: [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride

Purity: ≥99%

Product Details
Citations (2)
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Reviews

Biological Activity

Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

Technical Data

M.Wt:
393.27
Formula:
C17H16N6O.2HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
241799-10-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc

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Citations for Zoniporide dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Zoniporide dihydrochloride include:

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