Zoniporide dihydrochloride

Key Product Details

Product Description

Zoniporide dihydrochloride is a sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (K_i values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent ²²Na⁺ uptake in vitro (IC₅₀ = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC₅₀ = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Product Specifications for Zoniporide dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Zoniporide dihydrochloride

The following data is based on the product molecular weight 393.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.71 mL	25.43 mL
5 mM	0.51 mL	2.54 mL	5.09 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Marala Zoniporide: a potent and highly selective inhibitor of human Na⁺/H⁺ exchanger-1. Eur.J.Pharmacol. 2002 PMID: 12223226
• Clements-Jewery Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na⁺/H⁺ exchanger isoform-1, in an experimental model of cardiopulmonary bypass. Br.J.Pharmacol. 2004 PMID: 15037516
• Knight A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J.Pharmacol.Exp.Ther. 2001 PMID: 11259552

Product Documents for Zoniporide dihydrochloride