Neuroligin 4X/NLGN4X Proteins and Enzymes

Neuroligin 4 (NLGN4, NL4 or NL4X) is a transmembrane glycoprotein that is postsynaptically expressed on neurons and initiates excitatory presynapse maturation through binding to select isoforms of beta-Neurexin. NLGN4 also binds Syntrophin-gamma 2 intracellularly. Mutations of NLGN4 are associated with rare cases of autism, Asperger, or Tourette syndromes.