3 results for "Nicotinic Acetylcholine R alpha 4/CHRNA4" in Products
Nicotinic Acetylcholine R alpha 4/CHRNA4 Products
CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. CHRNA4 is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in CHRNA4 cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in CHRNA4 that provide protection against nicotine addiction have been described.
Positive allosteric modulator of α4β2 nAChRs; also muscle-type nAChR inhibitor
| Chemical Name: | 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanamine hydrochloride |
| Purity: | ≥98% |
Positive allosteric modulator of α4β2 nAChRs
| Chemical Name: | 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile |
| Purity: | ≥98% |
Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
| Chemical Name: | 3-(2-Chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole hydrochloride |
| Purity: | ≥98% |
