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PAK Compounds
P21-activated kinases (PAKs), EC 2.7.11.1, are serine/threonine kinases that are effector proteins for the Rho GTPases Cdc42 and Rac. Six PAK isoforms have been identified to date, which can be split into two groups: group I - PAK1, PAK2 and PAK3; and group II - PAK4, PAK5 and PAK6. The PAK isoforms have varying levels of expression and tissue distribution, although they are all highly expressed in the nervous system.
Group A PAKs exist as homodimers in their inactive state, where their ...
Negative control of NVS PAK1 1 (Cat. No. 6132)
| Chemical Name: | (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide |
| Purity: | ≥98% |
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