22 results for "GTPase Inhibitors" in Products
GTPase Inhibitors
GTPases are a large group of enzymes that catalyze hydrolysis of the γ phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is essential for catalytic activity. GTPases have essential roles in signal transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular transport regulation.
There are six main families of GTPases; heterotrimeric G protein GTPases (E.C. 3.6.5.1), small monomeric GTPases (E.C. 3.6.5.2), protein-synthesizing (translational) GTPases (E.C. 3.6.5.3), signal-recognition-particle GTPase (E.C. 3.6.5.4), dynamin GTPases (E.C. 3.6.5.5) and tubulin GTPases (E.C. 3.6.5.6).
Selective inhibitor of Rac1-GEF interaction; antioncogenic
| Chemical Name: | N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride |
| Purity: | ≥98% |
Potent Rac family inhibitor
| Chemical Name: | 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride |
| Purity: | ≥98% |
Non-competitive dynamin inhibitor
| Chemical Name: | 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide |
| Purity: | ≥98% |
Selective Cdc42 Rho family inhibitor
| Alternate Names: | CID 2950007 |
| Chemical Name: | 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide |
| Purity: | ≥98% |
Dynamin I inhibitor
| Chemical Name: | 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide |
| Purity: | ≥98% |
DOCK2-Rac1 interaction inhibitor
| Chemical Name: | 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione |
| Purity: | ≥98% |
Epac inhibitor
| Chemical Name: | α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile |
| Purity: | ≥98% |
Rho inhibitor
| Chemical Name: | D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride |
| Purity: | ≥98% |
Potent farnesyl diphosphate (FPP) synthase inhibitor
| Alternate Names: | Zometa |
| Chemical Name: | [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid |
| Purity: | ≥98% |
Gα-protein inhibitor; potent inhibitor of Gq/11 signaling
| Chemical Name: | (R)-1-((3S,6S,9S,12S,18R,21S,22R)-21-acetamido-18-benzyl-3-((R)-1-methoxyethyl)-4,9,10,12,16,22-hexamethyl-15-methylene-2,5,8,11,14,17,20-heptaoxo-1,19-dioxa-4,7,10,13,16-pentaazacyclodocosan-6-yl)-2-methylpropyl (2S,3R)-2-acetamido-3-hydroxy-4-methylpentanoate |
| Purity: | ≥95% |
Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis
| Chemical Name: | 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone |
| Purity: | ≥98% |
Sec7-specific GEF inhibitor; selective for cytohesin family
| Chemical Name: | N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide |
| Purity: | ≥98% |
Selective ARF6 inhibitor
| Chemical Name: | 3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one |
| Purity: | ≥98% |
Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
| Purity: | ≥95% |
Dynamin inhibitor; analog of dynasore (Cat. No. 2897)
| Alternate Names: | Dyngo 4a |
| Chemical Name: | 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide |
| Purity: | ≥98% |
High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
| Chemical Name: | 2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride |
| Purity: | ≥98% |
Selective Epac2 inhibitor
| Chemical Name: | 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole |
| Purity: | ≥98% |
Rac inhibitor
| Chemical Name: | N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine |
| Purity: | ≥98% |
Epac2 inhibitor
| Chemical Name: | 1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene |
| Purity: | ≥98% |
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis
| Chemical Name: | [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone |
| Purity: | ≥98% |
Geranylgeranyltransferase-I (GGTase-I) inhibitor
| Chemical Name: | (2R)-3,3,3-Trifluoro-2-methoxy-1-[(7R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-1-propanone hydrochloride |
| Purity: | ≥98% |
Potent covalent inhibitor of the RAS domain of the PI3K/p110α interaction
| Chemical Name: | 5-((1R,2S,5S)-2-(2-Chloro-3-fluorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl)-N-((R,E)-4-(methylsulfonyl)but-3-en-2-yl)pyrazine-2-carboxamide |
| Purity: | ≥98% |
