Photoactivatable Cross-linking Probes Small Molecules and Peptides

Photoactivatable Cross-Linking Probes are unnatural amino acids which are incorporated into proteins, and on exposure to light of a specific wavelength form covalent crosslinks. Triggering of this reaction by light enables precise temporal control and allows for the selective and potent inactivation of protein function. Photoreactive UAAs can be used to investigate the function of proteins, such as ion channels, transporters and GPCRs.