Plakophilin 4, also known by its gene name PKP4, has multiple transcript variants, however only two have been fully characterized. Isoform 1 has 1,192 amino acids and is approximately 132 kDa and the shorter 1,149 amino acid long isoform is approximately 127 kDa. Plakophilin 4 is a member of the Beta Catenin family and the Plakophilin subfamily of Armadillo-like proteins. Plakophilin 4 regulates Rho activity during cytokinesis and may be implicated in the regulation of junctional plaques. Current research on Plakophilin 4 is being performed relating to several diseases and disorders including Alzheimer's Disease, schizophrenia, renal cell carcinoma and cardiomyopathy. PKP4 interacts with Presenilin 1, Erbin, OSGEP, Desmoplakin and GABARAP.
![SDS-PAGE: Recombinant Human Plakophilin 4 GST (N-Term) Protein [H00008502-Q01]](https://resources.rndsystems.com/images/products/qc_test-H00008502-Q01-1.jpg "SDS-PAGE: Recombinant Human Plakophilin 4 GST (N-Term) Protein [H00008502-Q01]")
