PLC-beta 4 Small Molecules and Peptides

Phosphoinositide-specific Phospholipase C (PLC) is an essential signal transduction molecule that catalyzes the hydrolysis of the cellular membrane phospholipid Phosphatidylinositol 4,5-bisphosphate (PIP₂) to generate the second messengers Inositol 1,4,5-trisphosphate (IP₃) and Diacylglycerol (DAG). IP₃ and DAG then initiate the release of calcium from intracellular stores and the activation of Protein Kinase C, respectively. Currently, thirteen PLC isozymes have been identified and are divided ...