Catalog Number: 1941
Chemical Name: 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Biological Activity
Activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate formation in a variety of cell types. Also inhibits growth of the leukemic cell lines U937 and THP-1.

Negative Control also available.

Technical Data
  • M.Wt:
    343.36
  • Formula:
    C16H16F3NO2S
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    200933-14-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Identification of a compound that directly stimulates phospholipase C activity.
    Bae et al.
    Mol.Pharmacol., 2003;63:1043
  2. Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation.
    Krjukova et al.
    Br.J.Pharmacol., 2004;143:3
  3. The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis.
    Lee et al.
    Cancer Lett., 2005;222:227
Citations:

The citations listed below are publications that use Tocris products. Selected citations for m-3M3FBS include:

5 Citations: Showing 1 - 5
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  1. TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
    Authors: Shambharkar Et al.
    PLoS One 2015;10:e0127480
  2. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
    Authors: Rioult-Pedotti Et al.
    J Gen Physiol 2015;10:e0124986
  3. Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors.
    Authors: Semple-Rowland Et al.
    PLoS One 2014;8:e83378
  4. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    PLoS One 2013;33:11361
  5. Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation.
    Authors: Krjukova Et al.
    Br J Pharmacol 2004;143:3
Tocris Small Molecules
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o-3M3FBS

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