PRDC/GREM2 Proteins and Enzymes

PRDC (protein related to DAN and Cerberus) is a secreted, cysteine knot-containing BMP antagonist belonging to the Cerberus/DAN (CAN) family. Mammalian CAN family members, including Gremlin, DAN, Cerberus, COCO, SOST, and USAG-1, have the conserved 6 cysteine residues that form a cysteine knot, and two additional cysteine residues located in the cysteine knot loops that form an additional intrasubunit disulfide bond. Some members of this family, including PRDC, have an additional cysteine residue used for dimerization.