Chemical Name: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester
Biological ActivityPACMA 31 is an irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment.
Xu et al.
Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase.
Ge et al.
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